1-Testosterone™ by Hi-Tech Pharmaceuticals is based upon a naturally occurring metabolite for many animals including man that has properties far different from standard testosterone in the body. 1-Testosterone™ is more of a mild hormone that will give you cleaner gains and dramatic strength increases. There are three prohormones to this compound:1-androstenedione, 1-androstenediol and 1-Androsterone aka 1-androstene-3b-ol-17-one. Of the three, only 1-androsterone is still available on the U.S. market, and this is what Hi-Tech manufactures using its proprietary Cyclosome™ Delivery system for increased bioavailability.†

THE SCIENCE

In a recent study released in the Journal of Applied Physiology, the oral prohormone 1-androstene-3b-ol-17-one which converts in the liver to 1-Testosterone was as potent milligram-for-milligram to Testosterone Enanthate, the gold standard for Testosterone products. Very few dietary supplements have been subjected to a clinical study. However, the active prohormone 1-androstene-3b-ol-17-one was the subject of a clinical study at the West Texas A&M University, the California Baptist University and the University of Texas at Austin. The results showed 1-androstene-3b-ol-17-one to be significantly more powerful than it would appear structurally. The 9 males gained an average lean mass of 10.4 lbs and an increase in strength of 92.2 lbs in total load on bench/squat/deadlift. These are significant gains from a prohormone. The researchers concluded that the prohormone supplement contributed to robust improvements in muscle mass and strength in resistance trained. Although repeated studies are necessary to substantiate the efficacy of any compound, it’s safe to say that 1-androstene-3b-ol-17-one definitely packs a punch.

1-Testosterone would give you clean gains that are very dry and lean in nature. This means you won’t get a lot of bloat or estrogen activity with this prohormone. The lack of estrogen actually causes most people to stack this steroid with 4-andro or another “wet” compound. This helps potentiate the gains and increase the “comfort” of the cycle. 1-Testosterone™ will help give you clean gains that are very sustainable and help your strength go through the roof .

1-Testosterone Structure  

1-Testosterone has a structure similar to testosterone but the double bond is in a different place. 1-Testosterone is a 1,2-double bond instead of a 4,5-double bond in its A ring. This slight modification means that the molecule is subject to different metabolism than standard testosterone. It cannot be converted to estrogen via aromatase nor can it be turned into DHT. This makes it a very stable molecule and resists most traditional routes of metabolism. A 2006 study determined that 1-testosterone has a high androgenic and anabolic potency even without being metabolized. 1-testosterone binds in a manner that is highly selective to the androgen receptor (AR) and has a high potency to stimulate AR-dependent transactivation. 1-Testosterone has an anabolic to androgenic ratio of 200/100, which is superior to testosterone.

With 1-Testosterone™, many users report a hardening effect and an increase in vascularity. 1-Testosterone™ appears to be best used for size gains, although it provides the user with incredible strength gains as well. 1-Testosterone™ is considered a “dry” compound which can be used during cutting phases yet because of its strength is can also be useful during a bulking phase.